Which CAS numbers are listed?

3-[3-(Trifluoromethyl)phenyl]propanal, CAS 21172-41-8, is listed. It is a key fluorinated intermediate used in cinacalcet synthesis.

Can we take only the intermediate, or only API?

Yes. The two layers are modular. Many partners start with the fluorinated aldehyde, then add API once the route and impurity file are firm.

Why does aldehyde stability matter?

The aldehyde is reactive. Assay, related substances, moisture and storage conditions have to be controlled so downstream conversion and API quality stay reliable.

Who is this program for?

Marketing-authorisation holders, regional manufacturers and distributors who need qualified cinacalcet intermediates or API. Not for patients or retail dispensing.

Cinacalcet key intermediates and API

Oral calcimimetic — take the fluorinated intermediate, API, or both. CAS 21172-41-8 is listed for supply.

Calcimimetic
Fluorinated
Key intermediates
API

01CF3

Key intermediates

3-[3-(Trifluoromethyl)phenyl]propanal (CAS 21172-41-8), a key fluorinated building block on the cinacalcet route.

CAS 21172-41-8 listed for supply
Reactive aldehyde — stability and impurity control named in the spec

02Commercial

Active pharmaceutical ingredient

Cinacalcet API for secondary hyperparathyroidism and parathyroid-related hypercalcaemia programs.

Trifluoromethyl side chain is a structural element of the API
Assay, related substances, moisture and storage named in the spec

Key intermediate listed

3-[3-(Trifluoromethyl)phenyl]propanal (CAS 21172-41-8), a key fluorinated intermediate used in cinacalcet synthesis. Tell us the grade and volume range.

21172-41-8

Originator program — not a Unibest branded product

Calcimimetic

Oral class for parathyroid disorders (originator brand: Sensipar)

Industry context

Cinacalcet is an established oral calcimimetic used in the management of secondary hyperparathyroidism in dialysis patients and hypercalcaemia associated with parathyroid disorders. That is why a fluorinated intermediate and API need a commercial-ready supply — not a research-only catalogue.

For manufacturers and marketers

Marketing-authorisation holders

Regional manufacturers

Distributors

Not a consumer offer, and not originator-branded product.

Why this supply

The trifluoromethyl side chain is structural; the aldehyde is reactive — so assay, impurities, moisture and storage have to be named.

Fluorinated side chain of the API

3-[3-(Trifluoromethyl)phenyl]propanal carries the trifluoromethyl-containing side chain that is an important structural element of cinacalcet.

Aldehyde stability and impurity control

The reactive aldehyde functionality makes material stability and impurity control particularly important before downstream conversion.

Assay, moisture and storage

Consistent control of assay, related substances, moisture and storage conditions supports efficient conversion and reliable API quality.

Competitive manufacturing economics

A controlled intermediate supply can support competitive manufacturing economics on the cinacalcet campaign — we quote against specification and volume, not a list price on this page.

How a program starts

Same sequence whether you take the fluorinated intermediate, API, or both.

01
Scope
Grade, volume and whether you need CAS 21172-41-8, API, or both. We confirm what we can stand behind before work starts.
02
Align the file
Specification, CoA format, impurity expectations, moisture and storage — written down while gaps are still cheap to close.
03
Qualify supply
Listed intermediate lots and/or commercial API against that spec. Audit findings stay in the same program plan.
04
Deliver and hold
First shipment, then change control from one owner.

Frequently asked

No. This is a B2B supply of key intermediates and API for the molecule. It is not a consumer product and not offered under originator brand names, including Sensipar.

Ready to scope a supply?

Send the grade and a volume range. We reply with what we can stand behind.