Do you also supply tetrabutylphosphonium bromide?

Yes, CAS 3115-68-2 may be positioned separately as a general process reagent. It is not listed as a dabigatran-exclusive intermediate.

Can we take only the intermediate, or only API?

Yes. The two layers are modular. Many partners start with the chloroformate, then add API once moisture, hydrolysable impurities and storage are firm.

Who is this program for?

Marketing-authorisation holders, regional manufacturers and distributors who need qualified dabigatran intermediates or API. Not for patients or retail dispensing.

Dabigatran key intermediates and API

Oral direct thrombin inhibitor — take the chloroformate building block, API, or both. CAS 6092-54-2 is listed for supply.

Thrombin inhibitor
Oral
Key intermediates
API

01Route

Key intermediates

n-Hexyl chloroformate (CAS 6092-54-2), used to introduce the hexyloxycarbonyl functionality in dabigatran etexilate synthesis.

CAS 6092-54-2 listed for supply
Reactive, moisture-sensitive — assay, hydrolysable impurities and storage named in the spec

02Commercial

Active pharmaceutical ingredient

Dabigatran API for stroke-prevention and thromboembolic-disorder programs.

Reproducible downstream conversion starts with chloroformate control
Assay, hydrolysable impurities, moisture and storage named in the spec

Key intermediate listed

n-Hexyl chloroformate (CAS 6092-54-2), a route-specific building block used to introduce the hexyloxycarbonyl functionality during dabigatran etexilate synthesis. Tell us the grade and volume range.

6092-54-2

Originator program — not a Unibest branded product

Thrombin

Oral direct inhibitor (originator brand: Pradaxa)

Industry context

Dabigatran is an established oral direct thrombin inhibitor used for stroke prevention and the treatment and prevention of thromboembolic disorders. That is why a route-specific chloroformate building block and API need a commercial-ready supply — not a research-only catalogue.

For manufacturers and marketers

Marketing-authorisation holders

Regional manufacturers

Distributors

Not a consumer offer, and not originator-branded product.

Why this supply

Chloroformates are reactive and moisture-sensitive. Assay, hydrolysable impurities and storage have to be named so conversion stays reproducible.

Route-specific building block

n-Hexyl chloroformate (CAS 6092-54-2) is used to introduce the hexyloxycarbonyl functionality during dabigatran etexilate synthesis.

Moisture and hydrolysable impurities

Reliable control of assay, hydrolysable impurities, moisture and storage conditions matters because chloroformates are reactive and moisture-sensitive.

Reproducible conversion, tighter economics

Stable supply of this building block can support reproducible downstream conversion and cost-efficient API manufacturing. We quote against specification and volume — not a list price on this page.

Process reagent on request

Tetrabutylphosphonium bromide (CAS 3115-68-2) may also be positioned separately as a general process reagent rather than a dabigatran-exclusive intermediate.

How a program starts

Same sequence whether you take the chloroformate, API, or both.

01
Scope
Grade, volume and whether you need CAS 6092-54-2, API, the process reagent, or a mix. We confirm what we can stand behind before work starts.
02
Align the file
Specification, CoA format, hydrolysable impurities, moisture and storage — written down while gaps are still cheap to close.
03
Qualify supply
Listed lots and/or commercial API against that spec. Audit findings stay in the same program plan.
04
Deliver and hold
First shipment, then change control from one owner.

Frequently asked

No. This is a B2B supply of key intermediates and API for the molecule. It is not a consumer product and not offered under originator brand names, including Pradaxa.

Ready to scope a supply?

Send the grade and a volume range. We reply with what we can stand behind.