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Irinotecan key intermediates and API

Topo I — take SN-38, API, or both. SN-38 (CAS 86639-52-3) is in stock as a high-value advanced intermediate.

  • Topo I
  • SN-38
  • Key intermediates
  • API
01SN-38

Key intermediates

SN-38 (CAS 86639-52-3), the pharmacologically active metabolite and high-value advanced intermediate.

  • CAS 86639-52-3 held in stock
  • Camptothecin-derived structure, scoped to the grade you name
02Commercial

Active pharmaceutical ingredient

Irinotecan API for colorectal-cancer and combination-chemo programs.

  • Related-substance control starts with SN-38 quality
  • Assay, solvents, water and lactone structure named in the spec

SN-38 in stock

The pharmacologically active metabolite of irinotecan (CAS 86639-52-3), available for immediate supply. Tell us the grade and volume range.

86639-52-3

Originator program — not a Unibest branded product

Topo I

Inhibitor class for colorectal cancer (originator brand: Camptosar)

Industry context

Irinotecan is a well-established topoisomerase I inhibitor used in colorectal cancer treatment and multiple combination chemotherapy regimens. SN-38 is the pharmacologically active metabolite and a high-value advanced intermediate. That is why reliable intermediates and API need a commercial-ready supply — not a research-only catalogue.

For manufacturers and marketers

01

Marketing-authorisation holders

02

Regional manufacturers

03

Distributors

Not a consumer offer, and not originator-branded product.

Why this supply

SN-38 quality is the lever on downstream synthesis, related substances, and batch-to-batch reproducibility.

01

SN-38 quality drives the route

Because of its complex camptothecin-derived structure, SN-38 quality directly affects downstream synthesis efficiency and control of irinotecan-related substances.

02

Lower purification burden

A reliable SN-38 supply helps API manufacturers reduce purification burden on the irinotecan campaign.

03

Stereochemistry and reproducibility

Consistent SN-38 helps maintain stereochemical consistency and strengthen batch-to-batch reproducibility.

04

Named quality controls

Key considerations include assay, related substances, residual solvents, water content and control of the lactone structure.

How a program starts

Same sequence whether you take SN-38, API, or both.

  1. 01

    Scope

    Grade, volume and whether you need SN-38, API, or both. We confirm what we can stand behind before work starts.

  2. 02

    Align the file

    Specification, CoA format and impurity expectations — including lactone structure — written down while gaps are still cheap to close.

  3. 03

    Qualify supply

    Stock SN-38 and/or commercial API against that spec. Audit findings stay in the same program plan.

  4. 04

    Deliver and hold

    First shipment from stock or campaign, then change control from one owner.

Frequently asked

No. This is a B2B supply of key intermediates and API for the molecule. It is not a consumer product and not offered under originator brand names, including Camptosar.

Ready to scope a supply?

Send the grade and a volume range. We reply with what we can stand behind.