Unibest

UB029

TargetsKV1.3 (Oral)
IndicationsInflammatory bowel disease
ClinicalUS - IND、AU - IND、CN - IND
TherapeuticsImmunology & Inflammation
ModalitiesSmall Molecule

Exclusive Summary

  • Potential First-in-Class oral Kv1.3 inhibitor that selectively targets Effector Memory T (TEM) cells, offering a safer immunomodulatory approach compared to broad immunosuppressants.
  • Superior pre-clinical efficacy demonstrated in IBD models against standard-of-care Mesalamine and the JAK inhibitor Tofacitinib.
  • Proprietary ASD (Amorphous Solid Dispersion) formulation technology significantly enhances bioavailability (>20-fold) and ensures high tissue concentration in the intestine.
  • Validated high-value asset class: comparable pipeline assets (e.g., DES-7114) have secured $500M+ deals, making UB029 an attractive licensing opportunity for partners seeking safe oral IBD therapies.

Asset Materials

UB029 Asset Materials

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