Unibest

UB350

TargetsGLP-1; GLP-2
IndicationsObesity; Type 2 diabetes mellitus
ClinicalKR - II
TherapeuticsMetabolic & Endocrinology
ModalitiesFusion Protein

Exclusive Summary

  • Unique Mechanism (First-in-Concept): A rare GLP-1/GLP-2 dual agonist focusing on 'Healthy Weight Loss.' The GLP-2 component promotes lean mass preservation while reducing fat, addressing the critical issue of muscle loss associated with current GLP-1 therapies.
  • Superior Safety Profile: Preclinical toxicity studies (26 weeks) show no evidence of hyperplasia in the stomach, intestine, or thyroid, offering a cleaner safety profile compared to Semaglutide and Teduglutide for long-term use.
  • Outstanding Cost Efficiency: High-yield manufacturing (>7 g/L) results in extremely low Cost of Goods Sold (COGS), providing significant flexibility for global pricing strategies and reimbursement negotiations.
  • Delivery Innovation: Beyond the injectable form, the asset includes a validated oral capsule version (UB351) with remarkably high bioavailability (80-160%), enabling a potential 'Once-Weekly Oral' blockbuster product.

Asset Materials

UB350 Asset Materials

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